Most clinical insights are based on static measures and aggregate insights. We are interested in the dynamic changes able to be tracked by smartphones and wearables- "personal digital heath technologies". The more we focus at the n=one level the more akward it seems to assume that a priori information should be borrowed directly from others. The talk will review past efforts on stress and pregnancy, current efforts on Bipolar disease with UK Bipolar, and emerging efforts on forecasting frailty using dynamic resilience. The last part of the lecture will discuss how rare clinical outliers can point the path to discovering new therapies.
