In the field of active matter there have been extensive studies in the context on self-propelled particles and phase-separation. However, various interesting features arise at the molecular scale, particularly in the context of molecular machines, i.e. enzymes. Here, through a mechanistic framework of molecular machines, we exploit the intriguing non-equilibrium features that emerge at the nano-scales. These include descriptions that allows us to extract rules for the de novo design of enzymes as well as new mechanisms for the synchronization and cooperation of molecular oscillators.
