Collagen is by far the most abundant protein in ECM and human body. It accounts for 90% of bone matrix protein content. Being one of the main structural biomaterials, it organises, directs and affects a multitude of multicellular processes, from bone mineralisation to cancer cell invasions. The ability to form fibres, bundles of fibres, and intricate fibrillar matrices underlies its ubiquity. Despite its importance, the physical principles of organisation of even the most elementary of collagen fibrillar structures, the microfibril, remain unknown. We will discuss them in this talk.
